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First, the reduced levels of volatile toxicants are likely to be a consequence of the smaller ratio of internal volume to paper surface area in reduced circumference cigarettes, facilitating greater diffusional losses through the cigarette paper as the smoke travels down the tobacco rod during a puff

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However, as the link between smoking and cancer became clearer, smoking declined in both men and women

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i.e., the 1:2.55 dose equivalence between cannabis joints and tobacco cigarettes for adverse effects on lung function [107]