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After the comment periods ended, the FDA reviewed and responded to thousands of comments for both rules, which was a lengthy process

The tobacco chemicals create a sticky film that traps food debris and bacteria, which leads to enamel wear that exposes softer, easily stained layers underneath, gum disease that reveals more tooth surface for pigments to attack, persistent bad breath from bacterial buildup, and extra plaque and tartar that lock stain molecules in place

There was heterogeneity in the reported RRs across studies, but our meta-analytic method fit the data and covered the estimated residuals (Extended Data Fig

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