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Among the tobacco-related diseases considered, the highest PAF values, which represent the proportions of hospitalizations for the disease attributable to tobacco smoking, were observed for laryngeal cancer, with smoking contributing to approximately 75% of the reported hospitalizations, followed by COPD (75%) and lung cancer (74%)

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But lung cancer rarely causes symptoms in the early stages, when its easier to treat

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The study, published in Cancer Research , analyzed the epigenetic effects of tobacco and e-cigarettes on DNA methylation in over 3,500 samples to investigate the impact on cells that are directly exposed to tobacco (e.g., in the mouth) and those that are not directly exposed (e.g., in blood or cervical cells)