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Otsu and his colleagues found that after 24 hours of exposure, more cells died in cultures that were exposed to cigarette smoke extract and heated tobacco aerosolsincluding those that did not contain nicotinecompared with cells that were not exposed to smoke or tobacco

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However, the era in which a piece was crafted has a considerable impact in determining a pipe's desirability and value

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We excluded non-epithelial tumors of the head and neck, metastatic HNC, and recurrent HNC, as these were not included in the GBD study

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