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Serum Concentrations of Cotinine and Trans-3-Hydroxycotinine in US Adults: Results From Wave 1 (20132014) of the Population Assessment of Tobacco and Health Study Connie Sosnoff, Kevin Caron, J Akins, Kristin Dortch, Ronald Hunter, Brittany Pine, June Feng, Benjamin Blount, Yao Li, Bemmel van, Heather Kimmel, Kathryn Edwards, Maciej Goniewicz, Dorothy Hatsukami, Castro de, John Bernert, Stephen Arnstein, Nicolette Borek, Ying Deng-Bryant, Elena Mishina, Charles Lawrence, Andrew Hyland, Stephen Hecht, Kevin Conway, James Pirkle, Lanqing Wang Nicotine & Tobacco Research 7

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Veterinarians need to assess the dosage carefully, as overdose leads to severe complications, including respiratory depression and prolonged sedation

They looked at a potential delaying effect, smoking patterns among current and former smokers, the association with passive smoking, and the consistency across clinical subtypes