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National Cancer Institute published in January 2017 predicted that 8 million people around the world would die from smoking each year by 2030, and the global economy would lose $1 trillion annually as a result

Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers

We also found differences in demographic characteristics and use behaviors

Agents who survived transitioned between tobacco use states (i.e., Transition Sub-Model), and finally, new agents were introduced through birth and immigration on an annual basis (See Figure 2)

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Maternal smoking is associated with several complications of pregnancy including abruption placentae, placenta previa, bleeding during pregnancy, premature and prolonged rupture of the membranes, and preterm delivery