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Nicotine has known pathological effects, mainly related to the excessive release of catecholamines, endothelial dysregulation and increased insulin resistance.90 Nicotine in electronic cigarettes has been shown to increase heart rate after overnight abstinence.91 Regarding lipid metabolism, nicotine in electronic cigarettes has been shown to increase the amount of circulating saturated fatty acids, decreasing the content of unsaturated fatty acids and inducing insulin resistance

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The good news is that IBS can be managed, and recovery is possible