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These substances damage blood vessels and lung tissue, sustain chronic inflammation, and create conditions in which cells begin to function abnormally, accumulating errors that the body eventually can no longer correct

Atherosclerosis develops as the first stage of vascular endothelial dysfunction

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Using data on age-standardized rates of GBD in China, India, Indonesia, the United States, Russia, and globally from 19902019, the results of the joinpoint regression analyses are shown explicitly in Table I and Figure 1