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Nicotine addiction is a chronic condition in which a person compulsively uses nicotine-containing products and cannot stop, even when facing harmful consequences

Addressing these gaps through rigorous future studies (e.g., well-controlled longitudinal cohorts, clinical trials, and mechanistic experiments adapted for adolescent participants) will be essential to draw more definitive conclusions and inform evidence-based public health guidance for youth vaping

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It has become the fifth most burdened and the third most deadly disease in the global economy and increases year by year