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Common headings include Whats in cigarette smoke?, How tobacco smoke causes disease, Secondhand smoke, Whats in e-cigarette aerosol?, Health effects, and How to quit. Whats often missing is a zoom-in on the micro-exposure of a single puffhow it behaves as a chemical micro-dose that still meaningfully shifts heart rate, blood vessel function, and airway reactivity within minutes

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(Alexei, 27, current IQOS user, monthly smoking) Acceptability Participants discussed several social consequences of using IQOS which encouraged their ongoing use