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Furthermore, we selected participants with minimal dependence on tobacco (and cannabis), which suggests that nicotinic facilitation was not purely due to the reversal of withdrawal effects

There were 28.6 million people aged 12 or older in 2016 who were past month illicit drug users (with a 95 percent confidence interval of 27.6 to 29.5 million), or 10.6 percent of people aged 12 or older (with a 95 percent confidence interval of 10.3 to 11.0 percent)

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Approximately 19.6% of middle and high school students in the United States have reported using ENDS containing nicotine