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IL-33/Treg axis mediates HBV plus DEN-induced liver cancer development To determine whether IL-33-activated Tregs contributed to cancer development in HBV+DEN-treated mice, we subjected Foxp3 Cre , ST2 flox/flox (TregST2 CKO ) mice in which ST2 was specifically deleted in Tregs to HBV+DEN liver carcinogenesis protocol (Fig