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Of course there is always the rare exception where a pipe smoker might have a pipe in his mouth from the moment they get out of bed and turn the lights off at night, but I have read many accounts where pipe smokers will only smoke their pipe once or twice a week at the most

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doi:10.1161/HYPERTENSIONAHA.111.176313 34

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Many doctors recommend reducing or quitting nicotine use when starting estrogen therapy, especially if you have additional cardiovascular risk factors.