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Shiffman, S., & Rathbun, S

In addition, CSE activates the NLRP3 inflammasome through ROS, causing the release of downstream IL-1 and IL-18 and other inflammatory factors, leading to functional changes such as autophagy, pyrolysis, and apoptosis of endothelial cells (56, 62, 63)

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This idea of being quiet and having lots of time to stare like Neanderthals at the stars and at the moons