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65 Smoking also induces tissue remodeling, a process that encourages overgrowth of smooth-muscle cells that form artery walls, resulting in thickening and stiffening of the arteries

Piaggeschi G, Rolla S, Rossi N, Brusa D, Naccarati A, Couvreur S, Spector TD, Roederer M, Mangino M, Cordero F, et al

Its Over 23

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The FTC test does not account for the wide range of smoking behaviors and compensation that occurs naturally among smokers, thus, the standardization has come under great criticism