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They include: Relaxation of the upper airway muscles caused by nicotine Increased upper airway inflammation Changes in sleep patterns (increased sleep deprivation, sleep fragmentation, etc.) More frequent sleep arousal caused by nicotine Research suggests that smoking can disrupt healthy sleep patterns

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Serum nicotine and serum cotinine levels from acute 120 mg/ml nicotine vaped animals were positively correlated (slope = 0.3916, intercept = 142.3, r (12) = 0.5562, * p = 0.0389

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