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I give them so much credit for working so hard year-round to make that a possibility. JDRF has received $250,000 directly from marathon organizers over five years, LaTurno says, and the total donations generated by the marathon for JDRF is even greater

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Progressively, throughout the day, nicotine's systemic threshold for pleasure and arousal and that for withdrawal symptoms rises, creating a recurring demand for cigarettes

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Medicine and Health Although physicians had raised concerns about the health hazards of smoking since the 1800s, from the 1920s to the 1940s the number of reports in medical journals implicating cigarette smoking as a cause of cancer (for example, Lombard and Doering New England Journal of Medicine 1928;198:481-7) and premature death (for example, Pearl in Science 1938;87:216-7) rose steadily