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Stopping nicotine use is the only reliable way to clear it: Hydration, exercise, and a healthy diet may support metabolism, but the most effective way to remove nicotine and cotinine from the body is to stop using nicotine products and allow time for natural elimination

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Sometime after the War of 1812, demand for a milder, lighter, more aromatic tobacco arose

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Many influential American revolutionaries, including Thomas Jefferson and George Washington, owned tobacco plantations, and were hurt by debt to British tobacco merchants shortly before the American Revolution

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