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The chemical components in tobacco smoke were covered comprehensively in IARC Monograph 83 (IARC 2004) and described in previous reports of the Surgeon General

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Up to now, some organisms have been well utilized in the process of tobacco aging and fermentation, but most of the functions of microorganisms have not been explored and elucidated

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Bekki K, Inaba Y, Uchiyama S, Kunugita N (2017) Comparison of chemicals in mainstream smoke in heat-not-burn tobacco and combustion cigarettes

If we believe the cases and controls are similar in other ways, we can make an argument for causality