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More broadly, the results suggest that the tobacco dependence-chronic disease association is unlikely to operate through a single mechanism

No single measure is known that would have as great an impact on the number of deaths attributable to cancer as a reduction in the use of tobacco. An estimated 80% of tobacco users live in LMICs

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These include more severe nicotine withdrawal symptoms, increased emotional sensitivity, and heightened stress reactivity. These barriers can increase the likelihood of relapse and require targeted support during cessation efforts