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While not all puffing parameters can be controlled across all subjects, a product use that includes the same number of puffs, puff duration, and puff interval as utilized in this study allows for standardization of nicotine intake to the extent possible in order to accurately characterize uptake and reduction in smoking urge

The 600-puff rating is an estimate based on the average inhalation length, typically around one second per draw, which allows for a direct comparison to the longevity of a pack of twenty

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In contrast, an independent study of the acute response of mice to IQOS exposure (12 days) showed a significant increase in oxidative stress and total lung glutathione, similar to the response after CS exposure 43

The bag will be inspected separately from your other carry-on luggage when you reach the airport

Beyond their unknown long-term effects on human health, the extended list of appealing flavours available seems to attract new never-smokers, which is especially worrying among young users