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In 1924, Ohioan Lloyd "Spud" Hughes filed a patent application for his original technique of treating tobacco with menthol, creating a cigarette that was "cooling and soothing to irritated membranes" while being allegedly "absolutely non-injurious" and "pleasant to the taste." A century later, his invention having become immensely popular among African American smokers, the menthol cigarette is on the verge of being completely prohibited throughout the United States

Liao J, Bai J, Pan T, Zou H, Gao Y, Guo J, et al

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[15] Kim Jong Il has called smokers one of the "three main fools of the 21st century", along with people who do not understand music or computers

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Addition of nicotine hydrogen tartrate in the drinking water of female Wistar Han rats and female C57Bl/6 mice for 4 weeks induced hyperplasia of the urinary bladder epithelium (60)