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By fixing the values of any of these inputs to the model, it is possible to simulate different scenarios

Concerns have been raised primarily because nicotine crosses the placental barrier and accumulates in the fetus 16 , and animal studies have shown that maternal nicotine use has adverse effects on the newborn 17

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Nicotine and Tobacco Research 2014: volume 17, issue 7 (registration and subscription required for full article)