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Noteworthy, SHBG treatment substantially improved the expression of PCG1a, which is naturally activated by PPAR, and normalized the protein expression of HIF-1, an important factor that supports proper MSCs functions

118 (4), e2012685118

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and other PASC manifestations (ageusia, anosmia, parosmia, skin rashes) 130,131

Conclusion Among these approaches, CBT serves as an adjunctive therapy for symptom management rather than a curative one, whereas GET is contraindicated due to its potential for harm