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The initial symptoms are mainly due to stimulatory effects and include nausea and vomiting, excessive salivation, abdominal pain, pallor, sweating, hypertension, tachycardia, ataxia, tremor, headache, dizziness, muscle fasciculations, and seizures

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Health claims were then made on the basis of these so-called studies, as when Chesterfields were advertised in 1952 under the assertion that Nose, throat, and accessory organs [were] not adversely affected after a six-month period of medical observation (including X-rays) by ear, nose, and throat specialists.

The impact of smoking relapse extends beyond physical health, influencing emotional well-being and confidence