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Their widespread use did not begin out of concern for health, as many people thought

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In this study, insula inactivation also disrupted "malaise" responses to lithium chloride injection, suggesting that the representation of negative interoceptive states by the insula plays a role in addiction

"Selye was one of the major scientists of the 20th century, he was nominated for a Nobel Prize 10 times," Petticrew says

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