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We first identified three key driving factors: population growth, aging, and epidemiological changes, and constructed the following mathematical model: the total burden of TREC equals the sum of contributions from each factor 21

Yet, far from being a peculiar condition, long COVID often resembles myalgic encephalomyelitis/chronic fatigue syndrome or ME/CFS: indeed, it is estimated that about half of all long COVID patients meet the criteria for ME/CFS, itself a poorly understood, draining condition

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Paradoxical effects of cigarette smoke and COPD on SARS-CoV-2 infection and disease

Smoking is a leading cause of: Lung, mouth, throat, and esophageal cancers Heart disease, stroke, and high blood pressure Chronic obstructive pulmonary disease (COPD) and emphysema Reduced fertility and pregnancy complications Erectile dysfunction and reduced immune function Stomach ulcers and delayed wound healing Even secondhand smoke poses serious health risks, increasing the likelihood of cancer, asthma attacks, heart disease, and sudden infant death syndrome (SIDS) among nonsmokers