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Ethics approval and consent to participate All experimental procedures were reviewed and approved by an Internal Ethical Committee (reference 06/2015), by the rgano Evaluador de Proyectos de la Universidad Miguel Hernandez de Elche, an authorized organ by the competent authority (Comunidad Autnoma de Madrid, CAM) to evaluate experimental procedures in animals (reference UMH.VR.MGN.01.16) and, authorized by CAM (regional Institutional Animal Care and Use Committee), reference PROEX 046/16