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Given the effect of PAHs on enhancing CYP1A2 activity, diabetic smokers may experience increased metabolite synthesis, potentially necessitating dosage adjustments

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4 EVALUATION AND SCREENING The American College of Obstetricians and Gynecologists recommends that clinicians ask about tobacco use (along with secondhand smoking) before pregnancy, throughout pregnancy, and during postpartum periods, and advise patients regarding the significant perinatal risks and the importance of quitting tobacco or nicotine use in any form, including e-cigarettes and vaping