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Instead of using an e-liquid like Juul or other e-cigarettes, new heat-not-burn devices, or HNB, such as Philip Morris IQOS heating systems smolder tobacco leaf at high temperatures and use vaping-type chemicals to turn nicotine into a vapor that users inhale

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However, the duration of smoking (log-rank test: p=0.105, Figure 2b) and dose of tobacco use every day (log-rank test: p=0.101, Figure 2d) were shown to have no significant influence on the clearance in the patients

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