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21 identified N-nitrosonornicotine in unburned tobacco using gas chromatographymass spectrometry (GCMS) and reported it as a potential carcinogen at concentrations ranging from 0.12 to 3.7 g/cigarette

The nicotine is released either directly through the skin or through a membrane system in contact with the skin

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Smoking can reduce GFR by damaging the glomerular structures involved in filtration

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