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Only one case with a precancerous lesion was observed

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Cimetidine Co-administration of an OCT2 inhibitor, cimetidine (300 mg four times daily), with varenicline (2 mg single dose) to 12 smokers increased the systemic exposure of varenicline by 29% (90% CI: 21.5%, 36.9%) due to a reduction in varenicline renal clearance

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2012, Internet World Stats, Pre-publication history The pre-publication history for this paper can be accessed here: Acknowledgements The study received financial support from the Norwegian Research Council (grant no