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Crosthwaite was most recently chief growth officer at Altria, and has worked in tobacco for more than 20 years

In immortalised human bronchial epithelial cells with normal P53 and KRAS genes, which model normal airways, the high-nicotine medium generated using e-cigarette vapour was toxic, reducing cell growth and triggering cell death, but it did not cause the cells to develop cancerous behaviours, according to Park

It comes as a campaign launches this week in the North East encouraging people to quit or take it right outside

Use 4 with caution

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This is understandably a question we get asked a lot