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As between-study heterogeneity can be underestimated or even zero when the number of studies is small 196,197 , we used Fishers information matrix to estimate the uncertainty of the heterogeneity 198 and incorporated that uncertainty into the final results

According to CDC statistics, 5.7 million adults in the US regularly use smokeless tobacco products that's about 2% of the adult population

They sifted out the weaker papers - ones that didn't have control groups, for example - and were left with 20

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