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Moreover, the urine levels of metabolites of acrylonitrile, acrolein, propylene oxide, acrylamide and crotonaldehyde, all of which are detrimental for human health, were significantly higher in e-cigarette -only users than in non-smoker controls, reaching up to twice the registered values of those from non-smoker subjects (Table 1) [9]

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[ 11 ] This prompted the Surgeon General to issue an Advisory on E-cigarette Use Among Youth, calling it an epidemic

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