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Irsigler GB, Visser PJ, Spangenberg PA

This approach takes advantage of differences between healthy and malignant cells, such as the absence of a drug target

Tesofensine, a pharmaceutical compound under investigation for weight loss treatment, has shown promising results in clinical trials

Specifically, all three classes of antibiotics induced a significant downregulation of crucial energy metabolites such as AMP, ADP, and NADP, which can impede bacterial energy production capacity and hinder essential biosynthetic pathways ( An intriguing aspect of the ROS response was observed, particularly in relation to downregulated antioxidant metabolites, such as glutathione, across all treatments