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80 However, metformin does not currently show clinical benefit in COPD patients without diabetes, and the results of a multicenter RCT that included 52 nondiabetic patients with acute exacerbations of COPD showed that metformin (up to 2 g/day for one month) failed to improve glycemia in hospitalized nondiabetic patients, and did not have a significant impact on validation metrics or clinical symptoms

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