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In line with this, exposure to 10% CSE and 12.5% CSE induced a ~2-3 fold increase protein levels of the anti-oxidant protein Manganese Superoxide Dismutase (Mn-SOD, Figure 3C), a marker of oxidative stress, with a similar increase in Mn-SOD expression upon exposure to 10% CSE and 12.5% CSE at the mRNA level (data not shown)

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Optimistically, they will contribute to taking the country another step farther away from the previous "cigarette century," during which the market for tobacco was dominated by a single deadly product, and toward a future with lower risks and a greater diversity of ways to consume tobacco and nicotine

Guillermo Paraje, Michal Stoklosa and Evan Blecher, Illicit trade in tobacco products: Recent trends and coming challenges, Tobacco Control , 31, 2 (2022): 257262

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