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if peripheral administration is unavoidable, dilute to 4.2 % and infuse slowly to minimize vein irritation and extravasation injury

When ADH5 expression is reduced in certain organs and cell types in individuals with dominant-negative ALDH2*2 alleles, the ability to metabolize endogenous formaldehyde may be significantly reduced, possibly resulting in endogenous formaldehyde accumulation

In Phase II , the liver needs to neutralize those "shards" so they can be safely removed from the body

10.1186/s40168-024-01858-1 [DOI] [PMC free article] [PubMed] [Google Scholar] Bravo J

Some patients might also experience headaches, lightheadedness, or stomach upset, such as mild nausea [2]

10.1105/tpc.18.00918 82 XuJ.XiaoJ