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So, to get the expected effects of nicotine, there must be enough of the drug in the brain to bind to the receptors

Yes, all great points, Leo

Despite efforts to curtail tobacco use 2 , the Chinese tobacco industry is still able to attract consumers through marketing tactics that can increase smoking susceptibility 3 , particularly efforts to attract populations where smoking has traditionally been less acceptable, including youth and women

"Soundgarden's Chris Cornell announces reunion"

(Interestingly today, very few of those ads can be found in the same magazines)

It usually takes a little bit of time to enjoy a given tobacco