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We then fit lowess smoothed curves for the association between age of smoking onset and mean GPH and GMH, to determine if there was a similar dose-response curve to COPD prevalence (Supplementary file Figure 2)

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If EC aerosol emissions are much less harmful than tobacco smoke 15,16,17 , it can be hypothesized that long term vaping is less likely to cause significant harm to the respiratory system of regular daily EC users with no previous smoking history

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