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Related Topic: Marijuana and Alcohol Some common combinations include: Marijuana and alcohol, especially in youth Heroin and alcohol, marijuana, psychedelics, stimulants or sedatives, especially in youth Opioids and tobacco Opioids and marijuana Opioids and alcohol, which is dangerous as they are both CNS depressants Opioids and sedatives like benzodiazepines, a combination that carries an FDA black box warning due to the risk of CNS depression and death Opioids and stimulants Related Topic Marijuana and Alcohol Polydrug Overdose A big challenge in polydrug overdoses is identifying and addressing the cause of the overdose

For example, leaves in the upper part of the plant are more exposed to sunlight than those in the lower part, and generally contain higher levels of nicotine and other alkaloids

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