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Consistently, in Gpr15 +/+ mice, prolonged cigarette smoke exposure in the TNBS model led to aggravated colitis, as reflected by greater weight loss, elevated DAI, colon shortening, and worsened histological and endoscopic scores, accompanied by increased Gpr15 expression (Supplementary Fig

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The first popular clearomizers were the CE4 and CE5 by Aspire, who also produced some of the most popular modern clearomizers with the Nautilus line

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