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Toxicol Sci 96:2129 Shin VY, Jin HC, Ng EK, Yu J, Leung WK, Cho CH, Sung JJ (2008) Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways