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Additionally, disruptions in lipid metabolic pathways, including phospholipid and sphingolipid metabolism, suggested a functional link to ER stress

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PMID: 33821640 Eur J Med ChemDiscovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutants

32 Contrary to early skin model studies, Hernandez et al 32 found only low or inconsistent levels of ROS and AGEs in systemic models, suggesting that DNA damage is not primarily ROS-mediated and instead may occur through mechanisms such as glycation or crosslinking of DNA repair proteins