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For example, nicotine can activate the nAChRs on cancer cells and induce the release of growth factors, such as vascular endothelial growth factor (VEGF) and IL-1 into the tumor microenvironment, which can increase tumor angiogenesis and therefore promote tumor growth

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Use of e-cigarettes remained unchanged from the previous year at 7%, while 2.6% of adults used smokeless tobacco, including nicotine pouches

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