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Single-cell and spatial multi-omics analysis reveal that targeting JAG1 in epithelial cells reduces periodontal inflammation and alveolar bone loss

[PubMed: 22080084] 303

10.1371/journal.pone.0058435 54 KaurB.SharmaP

Notably, under the latter experimental conditions, neutrophils were found to release remarkable amounts of biologically active G-CSF, as demonstrated by the capacity of supernatants harvested from R848-treated neutrophils to trigger a G-CSF-dependent STAT3 phosphorylation in heterologous neutrophils