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Clinical Features Gastric Ulcer Epigastric pain worse with meals Nausea, vomiting Weight loss may occur Duodenal Ulcer Epigastric pain relieved by meals but may recur 25 hours later Night pain common Often associated with hyperacidity Alarm Symptoms (Red Flags) Hematemesis (vomiting blood) Melena (black, tarry stools) Anemia, weight loss Persistent vomiting Suspected malignancy 5

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This, the researchers suggested, may signify that smoking delays development of the central nervous system