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overall trends and interactions, among adults and among cigarette smokers), we compared models with survey wave analysed using restricted cubic splines with three, four, and five knots (sufficient to accurately model trends across years without overfitting) using the Akaike information criterion (AIC)

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Nicotines effect on the brain Theres one other big concern when it comes to e-cigarettes and the brain: Research has found that a significant number of electronic nicotine devices generate vapor with potentially unsafe levels of manganese

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