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Alomari MA, Al-Sheyab NA

Japan is a notable exception: cartons there sometimes contain 25 packs, producing a 500-cigarette configuration that reflects different retail purchasing behavior in that market

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PMID 29459389

Since the 1950s, the dangers of smoking have been gradually raised, and it has been found that cigarettes are the cause of many very dangerous diseases

The FDA estimates that the annualized benefits of the proposed rule, primarily from improved public health and reduced smoking-related illnesses, would amount to over $1.1 trillion per year over a 40-year period, while the annualized costs to implement the rule would be $2.07 billion per year over the same period